Levamisole HCL
Levamisole Hydrochloride
CAS: 16595-80-5
Molecular Formula: C11H13ClN2S
Levamisole HCL - Names and Identifiers
| Name | Levamisole Hydrochloride |
| Synonyms | decaris citarinl kw-2-le-t Levamisole HCL Levamisole Hcl EP5 Levamisole Hydrochloride L-2,3,5,6-Tetrahydro-6-phenylimidazo-[2,1-6]-thiazole (-)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride 1-b)thiazole,2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride,(s)-imidazo( 1-b)thiazole,2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride,1-(-)-imidazo 1-b]thiazole,2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride,(S)-Imidazo[2 Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride,(S)- 1-b)thiazole,2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride,l-(-)-imidazo( (-)-(S)-2,3,5,6-tetrahydro-6-phenylimidazo [2,1-b] thiazole monohydrochloride |
| CAS | 16595-80-5 |
| EINECS | 240-654-6 |
| InChI | InChI=1/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/m1./s1 |
| InChIKey | LAZPBGZRMVRFKY-HNCPQSOCSA-N |
Levamisole HCL - Physico-chemical Properties
| Molecular Formula | C11H13ClN2S |
| Molar Mass | 240.75 |
| Melting Point | 266-267°C(lit.) |
| Boling Point | 344.4°C at 760 mmHg |
| Specific Rotation(α) | -128 º (c=5, H2O) |
| Flash Point | 9℃ |
| Water Solubility | 210 g/L (20 ºC) |
| Solubility | Water soluble 210G/L (20°C) |
| Appearance | White to nearly white crystalline powder |
| Color | White to almost white |
| Merck | 14,5459 |
| BRN | 4358988 |
| Storage Condition | 2-8°C |
| Refractive Index | -126 ° (C=1, H2O) |
| MDL | MFCD00012675 |
| Physical and Chemical Properties | White to light yellow crystalline powder, odorless, bitter. Melting point 227-229 °c. Soluble in water, methanol, ethanol and glycerol, slightly soluble in chloroform, ether; Difficult to dissolve in acetone. It is stable under the condition of re-acid, and easy to decompose and fail under alkaline conditions. |
Levamisole HCL - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S28A - S36 - Wear suitable protective clothing. S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | NJ5960000 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29349990 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
Levamisole HCL - Reference
| Reference Show more | 1. Li Yuhan, Wang Lu, Chen Chaoxi. Effects of Total Flavonoids from Cuttings on Immune Organs and Antioxidant Activities in Mice [J]. Chinese veterinary journal, 2020,56(01):113-115. 2. [IF = 7.182] Jiqing Tang et al."Curdlan oligosaccharides having higher immunostimulatory activity than curdlan in mice treated with cyclophosphamide." Carbohyd Polym. 2019 Mar;207:131 3. [IF = 7.514] Tingting Ma et al."Effects of co-fermented collagen peptide-jackfruit juice on the immune response and gut microbiota in immunosuppressed mice." Food Chem. 2021 Dec;365:130487 |
Levamisole HCL - Standard
Authoritative Data Verified Data
This product is (5)-(-)-6-phenyl-2, 3,5, 6-tetrahydroimidazo [2,1-6] thiazole hydrochloride. The content of C11H12N2S • HC1 shall not be less than 98.5% calculated on a dry basis.
Last Update：2024-01-02 23:10:35
Levamisole HCL - Trait
Authoritative Data Verified Data
- This product is white or white needle-like crystal or crystalline powder; Odorless.
- This product is easily soluble in water, soluble in ethanol, slightly soluble in chloroform, and slightly soluble in acetone.
melting point
The melting point of this product (General rule 0612 first method) is 225~230 ℃.
specific rotation
take the right amount of this product, precision weighing, add water to dissolve and quantitatively dilute to make a solution containing about 50mg per lml. Measured according to law (General rule 0621), the specific rotation is not less than -121.5 °.
Last Update：2022-01-01 14:21:14
Levamisole HCL - Differential diagnosis
Authoritative Data Verified Data
- take about 60mg of this product, add 20ml of water to dissolve, add 2ml of sodium hydroxide test solution, boil for 10 minutes, let cool, add several drops of sodium nitroprusside test solution, that is, red; After placed, the color gradually changed and shallow.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 325).
- This product water solution chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 14:21:14
Levamisole HCL - Exam
Authoritative Data Verified Data
clarity of the solution
take 2.0g of this product and add 50ml of water. After dissolution, the solution should be clarified; If it is turbid, it should not be more concentrated compared with No. 1 turbidity standard solution (General rule 0902 first method).
acidity
take the solution under the clarity of the solution, measured by law (General 0631), the pH value should be 3.5~5.0.
absorbance
take this product, with hydrochloric acid methanol titration solution (0.2mol/L) made of 1 mg per 1mL solution, according to UV-visible spectrophotometry (General 0401), at a wavelength of 310nm, the absorbance should not exceed 0.20. 2-iminopyranazolidine derivative: take 50mg of this product, Add 10ml of dilute ethanol and 25ml of water to dissolve it, add 5ml of ammonia test solution, and heat it in 50°C water bath for 5 minutes, make 50ml with appropriate amount of silver nitrate test solution 2ml and water, shake well, place it in 50°C water bath and continue heating for 10 minutes; If it is turbid, compare with control solution (take 2ml of standard sodium chloride solution, after diluted to about 40ml with water, add 1ml of nitric acid and 1ml of silver nitrate solution, then add an appropriate amount of water to make 50ml, shake well, and place in the dark for 5 minutes). 2, 3-dihydro-6-phenylimidazole [2,14] thiazole hydrochloride take this product, add methanol to make a solution containing 0.10g per 1 ml, as a test solution; Take another 2, 3-dihydro-6-phenylimidazole [2,1-6] thiazole hydrochloride control was prepared as a control solution containing 0.50mg per 1ml in methanol. According to the thin layer chromatography (General 0502) test, absorb the above two solutions each 5 u1, respectively, on the same silica gel G thin layer plate, with toluene-methanol-glacial acetic acid (45:8:4) for the developer, expand, dry, set iodine vapor color. If the test solution shows impurity spots corresponding to the control solution, the color of the test solution should not be deeper (0.5%) than the main spot of the control solution.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Last Update：2022-01-01 14:21:15
Levamisole HCL - Content determination
Authoritative Data Verified Data
take this product about 0.2g, precision weighing, add ethanol 30ml dissolution, according to the potential titration method (General 0701), with sodium hydroxide titration solution (O. 1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of sodium hydroxide titration solution (0.1 mol/ L corresponds to 24.08mg of C11H12N2S. HCI.
Last Update：2022-01-01 14:21:16
Levamisole HCL - Category
Authoritative Data Verified Data
anthelmintic and biological response regulator.
Last Update：2022-01-01 14:21:16
Levamisole HCL - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 14:21:16
Levamisole HCL - Levamisole HydrochJonide Tablets
Authoritative Data Verified Data
This product contains levamisole hydrochloride (C11H12N2S • HCI) should be 90.0% ~ 110.0% of the label amount.
trait
This product is a white tablet or sugar-coated tablet, White after removing the coating.
identification
take an appropriate amount of fine powder of this product (equivalent to levamisole hydrochloride 0.15g), add water 50ml, shake to dissolve levamisole hydrochloride, filter, filtrate identification under the item of levamisole hydrochloride (1), (3) the test showed the same response.
examination
- the dissolution of this product, according to the dissolution and release determination method (General rule 0931 first method), with water as the dissolution medium, the speed is 100 rpm, according to the law, after 30 minutes, 10ml of the solution was taken, filtered, and the filtrate was continued as a test solution.
- preparation of standard curve an appropriate amount of levamisole hydrochloride control was accurately weighed, dissolved in water and diluted to prepare a solution containing 0.4mg per 1 ml as a control solution. Take 1.0ml, 2.0ml, 3.0ml, 4.0ml and 5.0ml of the reference solution for precise measurement, and put them into lOOml measuring flask respectively, and add 0.1 mol/L sodium hydroxide solution diluted to the scale, shake, 0. The lmol/L sodium hydroxide solution is blank, and the first derivative spectrum is drawn in the wavelength range of 220 ~ 250nm, and the value of the peak zero amplitude D is measured, and the regression equation between the D value and the concentration c is obtained.
- determination of sample solution precise volume 5.0ml of filtrate was taken and placed in a 10ml( 25mg specification) or 20ml(50mg specification) measuring flask, dilute with 0.2mol/ L sodium hydroxide solution to the scale, shake, according to the method under the standard curve, measure the amplitude value, from the regression equation of the standard curve, the dissolution amount of each tablet was calculated. The limit is 80% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (about 0.2g equivalent to levamisole hydrochloride), put it in a separatory funnel, add 10ml of water, shake to dissolve levamisole hydrochloride, add 5ml sodium hydroxide solution, after slightly shaking, add human chloroform 50ml accurately, shake extraction, after static stratification, take the chloroform solution, filter through dry filter paper, take the filtrate 25ml accurately, add 15ml of glacial acetic acid and crystal violet indicator 1 drop, with perchloric acid titration solution (0.1 mol/L) titration to a blue color of the solution, and the results of the titration were corrected by a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol /L) corresponds to 24.08mg of C11H12N2S. HCI.
category
with levamisole hydrochloride.
specification
(l)25mg (2)50mg
storage
sealed storage.
Last Update：2022-01-01 14:21:17
Levamisole HCL - Levamisole hydrochloride enteric-coated tablets
Authoritative Data Verified Data
This product contains levamisole hydrochloride (C11H12N2S • HCI) should be 90.0% ~ 110.0% of the label amount.
trait
This product is an enteric-coated tablet, White after removing the coating.
identification
take an appropriate amount of fine powder of this product (about 0.15g equivalent to levamisole hydrochloride), add 50ml of water, shake to dissolve levamisole hydrochloride, filter, filtrate according to the identification of levamisole hydrochloride (1), (3) one trial showed the same response.
examination
- dissolution the dissolution and release of this product were determined according to the dissolution and release determination method (General rule 0931 first method 1). The rotation speed was 100 revolutions per minute, and the running time in the elution amount in the buffer was 60 minutes.
- 3.0ml of the filtrate under the acid elution amount item was taken, 0.2 ml of 1.0 mol/L sodium phosphate solution was added, and the mixture was shaken to obtain the test solution (1); the filtrate obtained under the elution amount in the buffer solution was used as the test solution (2). Add the appropriate amount of levamisole hydrochloride reference substance, precision weighing, add pH(6.8±0.05) solution [take hydrochloric acid solution (9-1000)750ml +0.2mol/L sodium phosphate solution 250ml, adjust the pH to 6.8±0.05] dissolve and dilute to make a solution containing 25ug per 1 ml as a control solution. Take 2ml of each of the reference solution and the test solution (1) and (2) and place them in the separating funnel respectively, add bromocresol green solution (50mg bromocresol green and 0.2mol/L potassium hydrogen phthalate solution 50ml), add 0.2mol/L sodium hydroxide solution to adjust pH to 4.5, dilute to ML with water, and shake, if necessary, filter) 3.0ml, shake well, precisely add 0401 ml of chloroform, shake for 1 min, and separate the chloroform solution after standing and stratification, according to UV-Vis spectrophotometry (general rule), the absorbance was measured at a wavelength of 420MN, and the elution amount of each tablet was calculated. The requirements shall be met.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product, remove the coating, precision weighing, fine, precision weighing an appropriate amount (about 0.2g of levamisole hydrochloride), set the separation funnel, add 10ml of water, after adding 5ml of sodium hydroxide solution to levamisole hydrochloride solution with shaking, add 50ml of human trichloromethane with little shaking, extract with shaking, and separate the three-gas methane solution after static stratification, filter through dry filter paper, take 25ml of continuous filtrate, add 15ml of glacial acetic acid and 1 drop of crystal violet indicator solution, and use perchloric acid titration solution (0.1 mol/L) titration to a blue color of the solution, and the results of the titration were corrected by a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol /L) corresponds to 24.08M g of C11H12N2S. HCI.
category
with levamisole hydrochloride.
specification
(l)25mg (2)50mg
storage
sealed storage.
Last Update：2022-01-01 14:21:18
Levamisole HCL - Levamisole Hydrochloride Granules
Authoritative Data Verified Data
This product contains levamisole hydrochloride (C11H12N2S • HCl) should be 90.0% ~ 110.0% of the label amount.
trait
This product is soluble granules.
identification
- take an appropriate amount of this product (approximately equivalent to levamisole hydrochloride O.lg ), add 25ml of water to the separating funnel, shake to dissolve levamisole hydrochloride, add 3ml of sodium hydroxide solution and 10ml of chloroform, shake to extract, separate and take the chloroform solution to dry on the water bath, the residue was dissolved by adding 2ml of dilute hydrochloric acid, and boiled with 20ml of water and 3ml of sodium hydroxide solution for 10 minutes and allowed to cool. Several drops of sodium nitrosoferricyanide solution were added, which showed red color.
- Take lg of this product, add 10ml of water to dissolve, and the aqueous solution shows chloride to identify the reaction of (1) (General rule 0301).
examination
- weight loss on drying the product is dried to constant weight at 105°C, and the weight loss shall not exceed 2.0% (General rule 0831).
- others should comply with the relevant provisions under The granule (General Principle 0104).
Content determination
take the contents under the difference of loading amount, mix evenly, grind finely, weigh an appropriate amount (about 0.2g equivalent to levamisole hydrochloride) accurately, put it in a separatory funnel, and add 10ml of water, after slightly shaking, chloroform 50ml was added, and the mixture was extracted by shaking. After static stratification, the chloroform solution was separated and filtered through dry filter paper, take 25ml of continuous filtrate, add 15ml of glacial acetic acid and 1 drop of crystal violet indicator solution, and use high-gas acid titration solution (0.1 mol/L) titration to a blue color of the solution, and the results of the titration were corrected by a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 24.08mg of C11H12N2S • HCl.
category
with levamisole hydrochloride.
specification
10g : 50mg
storage
sealed and stored in a cool and dry place.
Last Update：2022-01-01 14:21:19
Levamisole HCL - Levamisole hydrochloride syrup
Authoritative Data Verified Data
This product contains levamisole hydrochloride (C11H12N2S • HCl) should be 90.0% ~ 110.0% of the label amount.
trait
This product is a brown clear viscous liquid.
identification
take 10ml of this product, add 4ml of sodium hydroxide test solution, add 30ml of chloroform, fully shake, place, separate the chloroform liquid, evaporate, extract dissolved in water, add 2ml of sodium hydroxide test solution, boil for 10 minutes, let cool (filter if necessary), add a few drops of sodium nitroprusside ferricyanide test solution, that is, red, after placed, the color gradient is light.
examination
- relative density the relative density of this product (General 0601) should be 1.20~1.0.
- others shall comply with the relevant provisions under syrup (General rule 0116).
Content determination
take 25ml of this product with internal volume pipette, put it in a separatory funnel, wash out the attached liquid in the pipette with water, add 10ml of water, shake to dissolve levamisole hydrochloride, add 5ml sodium hydroxide solution, after slightly shaking, add 50ml three gas methane, shake extraction, after static stratification, separate chloroform solution, filter through dry filter paper, take 25ml of continuous filtrate, add 15ml of glacial acetic acid and 1 drop of crystal violet indicator solution, and use perchloric acid titration solution [0.05mol/L or 0.02mol/L(10ml:20mg) specification] titrate until the solution is blue, and the results of the titration are corrected with a blank test. Each 1 ml of perchloric acid titrant (0.05mol/L) or (0.02mol/L) corresponds to 12.04mg or 4.815mg of C11H12N2S • HCl, respectively.
category
with levamisole hydrochloride.
specification
(l)10ml:20mg (2) 100ml:0.8g (3)500ml:4.Og (4)2000ml:16.Og
storage
light shielding, sealed storage.
Last Update：2022-01-01 14:21:20
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